Plot:
Alice awakens in the Resident Evil mansion. Walking into the laser grid room and then jumps into the hospital room where she gets shot. Her body's thrown away with other Alice clones. The Umbrella Corporation has a lab in the desert fenced in surrounded by zombies.
Alice narrates how the T-Virus killed most humanity, and the planet dried up. She's motorcycling around the Southwest. Picking up a radio distress call, she goes to check on the people who tried to trap her. Dropping her in a pit with zombie dogs. She evades the dogs that escape the pit and go after the group.
A convoy (without the CW McCall song) led by LJ, Carlos Olivera, and Claire Redfield head down the road.
The Umbrella Corporation lab, Dr. Isaacs wants to use Alice's blood to domesticate the zombies. Unfortunately, the clones of Alice aren't good enough. Isaacs starts to train the zombies for servants.
Alice checks through more of the Southwest and seems to keep avoiding the Claire's convoy.
The convoy keeps searching for survivors besides trying to scavenge a motel. LJ gets bitten by a zombie. .
The clone Alice has some sort of psychic link to Alice. Original Alice accidentally uses her telekinetic power to lift her motorcycle and drop it.
The convoy discovers they're surrounded by zombie birds that start attacking them. As the LJ, Carlos, Claire and the others have to fight the zombie birds. Things aren't looking good until, Alice runs up to save Carlos. Afterwards, burying the dead, Carlos wonders why Alice left them.
Isaacs reports to his corporate bosses how important it is he needs to get Alice. They refuse to go after her.
The convoy learns about the Alaska base from Alice. They vote to go to Alaska but need more supplies which mean to resupply at Las Vegas.
Isaacs fakes an order to capture Alice.
A sanded over Las Vegas strip, the convoy starts looking and find a trailer full of zombies that attack. Machete Alice ensues. Isaacs is able to deactivate Alice from fighting. She deactivates the control.
In the melee, the zombiefied LJ bites Carlos. Alice goes back to zombie battling and heads after the Umbrella guys. Isaacs gets bitten by a zombie.
Back at the Umbrella lab, Isaacs keeps shooting himself up with the anti-virus. One of the aides shoots him but it doesn't stop Isaacs who now has protoplasmic tentacles.
The convoy spots the zombies around the lab. Alice wants to go after the anti-virus for Carlos. However, it is too cure him. He'll get them through. Driving a truck and crashes through the fence. Alice and the convoy get to the chopper. She stays behind as the chopper head off.
Examining the land, Alice finds a pile of dead clones. Heading underground, the lab is dark and ramshackled. She talks with the White Queen, the holographic AI. Telling her that Isaacs has mutated and apparently, Alice's blood could stop the T-Virus.
Searching for Isaacs, she finds a clone of her is a crèche. The zombies attack and that releases clone-Alice. Alice keeps looking for Isaacs in the Resident Evil mansion. The fight is on...Psychic powers versus Isaacs’s tentacles. In the laser room, Alice is fighting Isaacs-Tyrant. The grid cuts Isaacs apart. Things are looking bad as the lasers head for her. However, clone-Alice shuts the lasers to save the original.
Tokyo, Umbrella committee report when a holographic Alice calls in to warn them she coming after them.
Alice and clone-Alice look in the huge room of crèches full of more clone Alices.